{"id":2709,"date":"2024-06-10T08:51:07","date_gmt":"2024-06-10T01:51:07","guid":{"rendered":"https:\/\/hataphar.com.vn\/?p=2709"},"modified":"2024-08-26T12:10:12","modified_gmt":"2024-08-26T12:10:12","slug":"city-level-scientific-research-topic-evaluation-of-the-effect-of-liv-94-in-reducing-and-clearing-hbsag-in-patients-with-chronic-hepatitis","status":"publish","type":"post","link":"https:\/\/hataphar.com.vn\/en\/city-level-scientific-research-topic-evaluation-of-the-effect-of-liv-94-in-reducing-and-clearing-hbsag-in-patients-with-chronic-hepatitis\/","title":{"rendered":"Antitussive and expectorant activity of the herbal preparation Bophe-Hataphar\u2122\u00a0syrup containing dried extract of\u00a0Eriobotrya japonica\u00a0(Thunb.) Lindl. leaf"},"content":{"rendered":"

Conference Report: The 4th ASEAN PharmNET 2024 & The 2024 US-Thai Pharmacy Consortium Conference: The 30th Anniversary Commemoration<\/p>\n

1. Introduction:<\/strong><\/p>\n

Eriobotrya<\/i> japonica<\/i>\u00a0(Thunb.) Lindl. (commonly known as Loquat) is an evergreen fruit tree, only distributed in some northern provinces of Vietnam (LangSon, CaoBang, LaiChau). The Loquat leaf has been used in traditional herbal medicine for treating coughs and respiratory conditions. The main ingredient of Bophe-Hataphar\u2122 is dried extract of\u00a0E. japonica<\/i>\u00a0leaves and some anti-coughing herbal drugs such as\u00a0Platycodi<\/i> radix<\/i>,\u00a0Fritillaria<\/i> cirrhosa<\/i> bulbus<\/i>,\u00a0Zingiberis<\/i> rhizoma<\/i>. The herbal preparation was prepared in syrup form for this study.<\/p>\n

Objectives: <\/b>To evaluate the antitussive and expectorant activity of Bophe-Hataphar\u2122 syrup using\u00a0in vivo<\/i>\u00a0expreriments.<\/p>\n

2. Methods<\/strong><\/p>\n

For the antitussive assay:The antitussive effects were evaluated using a classical mice cough model induced by ammonia liquor. Codeine phosphate was used as a positive control. For the expectorant assay: phenol red secretion experiments were conducted to evaluate the expectorant activities of Bophe-Hataphar\u2122. NH4Cl was used as a\u00a0positive control.<\/p>\n

3. <\/strong>Results and Discussions<\/b><\/p>\n

The results showed that codeine phosphate at a dose of 30 mg\/kg significantly reduced coughs per 5 minutes compared to the control group (p<0.001). Bophe-Hataphar\u2122 exhibited potent antitussive effects, significantly reducing coughs in a dose-dependent manner. At doses of 7.2 ml\/kg and 14.4 ml\/kg,\u00a0the herbal preparation reduced coughs to 1 (0-3) and 3 (0-8) per 5 minutes, respectively (p<0.001), demonstrating its antitussive activity. There was no significant difference in cough reduction efficacy between doses (p>0.05).<\/p>\n

In the expectorant assay using the phenol red secretion mice model, the positive control NH4Cl at a dose of 1.5 g\/kg exhibited expectorant activity by significantly increase phenol red secretion when compared to the control group (p<0.05). Bophe-Hataphar\u2122 was evaluated for its ability to promote expectoration. The results showed that the herbal preparation significantly increased phenol red secretion, indicating expectorant activity. Both doses of Bophe-Hataphar\u2122 (7.2 ml\/kg and 14.4 ml\/kg) resulted in a 1.5-fold increase in phenol red secretion, similar to the positive control (p> 0.05).<\/p>\n

4. <\/strong>Conclusion<\/b><\/p>\n

Overall, the study demonstrated that Bophe-Hataphar\u2122 syrup has significant antitussive and expectorant activities\u00a0in vivo<\/i>. It effectively reduced coughing and promoted expectoration. This research is the first to report on antitussive and expectorant activity of herbal preparation containing dried extract of E. japonica <\/i>leaf as major ingredient.<\/p>\n","protected":false},"excerpt":{"rendered":"

Conference Report: The 4th ASEAN PharmNET 2024 & The 2024 US-Thai Pharmacy Consortium Conference: The 30th Anniversary Commemoration 1. Introduction: Eriobotrya japonica\u00a0(Thunb.) Lindl. (commonly known as Loquat) is an evergreen fruit tree, only distributed in some northern provinces of Vietnam (LangSon, CaoBang, LaiChau). The Loquat leaf has been used in traditional herbal medicine for treating […]\n","protected":false},"author":1,"featured_media":3184,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[141],"tags":[],"class_list":["post-2709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/posts\/2709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/comments?post=2709"}],"version-history":[{"count":3,"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/posts\/2709\/revisions"}],"predecessor-version":[{"id":3187,"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/posts\/2709\/revisions\/3187"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/media\/3184"}],"wp:attachment":[{"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/media?parent=2709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/categories?post=2709"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hataphar.com.vn\/en\/wp-json\/wp\/v2\/tags?post=2709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}